It is formed in large quantities by chemical reduction of benzoquinone. Melanin is the pigment in skin that gives it a brown color. This compound is a generalpurpose inhibitor, stabilizer, antioxidant, and intermediate. Osha table z1 limits for air contaminants 29 cfr 1910. May cause dizziness, nausea, sense of suffocation, increased respiratory rate, vomiting, pallor, muscle twitching, cyanosis bluish discoloration of skin due to deficient oxygenation of the blood, delirium. Get medical adviceattention p310 immediately call a poison centerdoctor p330 if swallowed, rinse mouth. Chemical product and company identification product name. Sewage sludge activated to phenol was found to oxidize hydroquinone3,4. Commission regulation eu no 2015830 of 28 may 2015. Qualitative and quantitative estimation of hydroquinone in. The dust my cause irritation of the nose, throat and upper respiratory tract. Hydroquinone is a watersoluble reducing agent making it an excellent polymerization inhibitor for acrylates. Hydroquinone decreases the formation of melanin in the skin. If medical advice is needed, have product container or label.
Safety data sheet according to 29cfr19101200 and ghs rev. Sigmaaldrich material safety data sheet date printed. In the presence of air and moisture, hydroquinone dust may react to form irritating quinone which forms a vapor at room temperature. Hydroquinone safety data sheet according to federal register vol. First aid eye contact immediately flush with large amounts of water for at least 30 minutes, lifting upper and lower lids. Hydroquinone is on the right to know hazardous substance list because it is cited by osha, acgih, dot, niosh, dep, iarc, nfpa and epa. Over the past several years, hydroquinone has become a controversial skincare ingredient for topical use. All products should be stored at a dry and ventilated location away from fire and other dangerous goods, and should avoid direct sunlight.
Black and white bleaching cream with hydroquinone at walgreens. May cause irritation of the nose and respiratory tract. Exposure controlspersonal protection components with workplace control parameters components casno. Members of the ectonox family, such as cnox, or enox1, are involved in plasma membrane transport pathways. Skin darkening is called epidermal hyperpigmentation and is caused by the deposit of too much melanin normal skin pigment in the skin.
Imports of hydroquinone in usa manufacturers of hydroquinone buyers of hydroquinone in usa. Achieve a more even tone with hydroquinone free skin lighteners and brighteners. Responses were not consistent across route of exposure, species or sex. It also finds use in topical skin creams and lotions for. Hydroquinone can be found on the following state righttoknow lists.
Product identifier product name hydroquinone product number fh01233 synonyms. Hydroquinone is an active allergen so repeated and prolonged exposure may cause skin sensitization. Ac12090, ac120910020, ac120910050, ac120915000, ac219930000, ac219930050 ac219930050, ac219930500, h329500 synonyms. The guide is intended to supplement training, material safety data sheets msdss, safety. Hydroquinone is linked to exogenous ochronosis, dermatitis and skin. Chemical properties of hydroquinone cas 123319 download as pdf file download as excel file download as 2d mole file predict properties. Material safety data sheet hydroquinone msds section 1. Hydroquinone reference material extrasynthese, hydroquinone.
All products should be stored at a dry and ventilated location away from fire and. Achieve a more even tone with hydroquinonefree skin lighteners and brighteners. Clinical director, innovative skincare topical hydroquinone is used frequently throughout the world as a skin bleaching agent. Substituted derivatives of this parent compound are also referred to as hydroquinones. The user must determine suitability of this information for his application. This staining is temporary and can typically be removed with soap and water washing, but its best to avoid benzoyl peroxidebased acne treatments and oxygeninfusing skin care treatments, which.
Hydroquinone is a phenolic compound, which is naturally found in coffee, tea and wine. Registrationlogin is required to view the sheets which appear to be all in pdf format. Hydroquinone is a watersoluble reducing agent making it an excellent polymerization inhibitor for acrylates it also finds use in topical skin creams and lotions for reducing the signs of age. Hydroquinone patient instructions what is hyperpigmentation. Shop lovelyskin for exclusive offers, free shipping and samples. Sewage sludge activated to phenol was found to oxidize hydroquinone 3,4. Page 2 of 14 safety data sheet section 2 hazards identification continued label elements danger hazard statements harmful if swallowed causes skin irritation causes serious eye damage. First aid measures description of firstaid measures general advice. The frequency of fetal death was increase among rats fed 2500 mgkg of hydroquinone. Hydroquinone did not cause birth defects when given orally to pregnant rats at doses up to 300 mgkgday. Hydroquinone is commonly used as a biomarker for benzene exposure. These enzymes exhibit both a hydroquinone nadh oxidase activity and a protein disulfidethiol interchange activity in series, with each activity cycling every 22 to 26 minutes scarlett et al. Buy hydroquinone cas 123319, a quinone small molecule with efficacy as a topical preparation, from santa cruz.
Hydroquinone topical is used to lighten areas of darkened skin such as freckles, age spots, chloasma, and melasma. It is used in photographic, chemical and cosmetic industries. The presence of hydroquinone in normal individuals stems mainly from direct dietary. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. It may be found in concentrations up to 15% or more but a doctors prescription is required by the fda united states for. View or download the hydroquinone msds material safety data sheet or sds for 822333 from milliporesigma. Commercially available as oil concentrate and as dust concentrate. Show this safety data sheet to the doctor in attendance. Date hs code description origin country port of discharge unit quantity value inr per unit inr nov 22 2016. Pure hydroquinone does not readily form a vapor at room temperature. Hydroquinone has been detected in cigarette smoke mainstream and. Hydroquinone, also known as benzene1, 4diol, is an aromatic organic compound which is a type of phenol, having the chemical formula c6h4oh2. Acgih threshold limit values 01 2010 pel 2 mgm3 us. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database.
Material safety data sheet hydroquinone 2 ingestion. It is topically applied to treat melisma, freckles and senile lentigines. Hydroquinone cas 123319 scbt santa cruz biotechnology. Material safety data sheet hydroquinone 6 information in this msds is from available published sources and is believed to be accurate. Hydroquinone, usp hydroquinone, usp sds preparation date 10172016. Hydroquinone also may be an important factor in the defense mechanis some insects, most notably the bombardier beetle hsdb, 2005 hydroquinone may be released into the environment during its produ. Amended safety assessment of hydroquinone as used in cosmetics. Value control parameters update basis hydroquinone 123319 twa 1 mgm3 20080101 usa. The rate of malformations was not significantly increased among the offspring of rabbits administered doses up to 150 mgkgday during pregnancy. Use of hydroquinone with any products containing benzoyl peroxide, hydrogen peroxide, or other peroxides may cause temporary staining of the skin. No warranty, express or implied, is made and qorpak assumes no liability resulting from the use of this msds. It works by inhibiting an enzyme reaction in skin cells.
Amended safety assessment of hydroquinone as used in. Hydroquinone msds 822333 milliporesigma emd millipore. Black and white bleaching cream with hydroquinone walgreens. Hydroquinone, also known as benzene1,4diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula c 6 h 4 oh 2. May cause severe irritation of the digestive tract. Extrasynthese is a leading chemicals company that provides customers with highquality hydroquinone standard reference material. Hydroquinone according to regulation ec no 19072006, annex ii, as amended.
Despite the controversy, its abundantly clear is that hydroquinone is a wellresearched ingredient, incredibly effective for its intended purpose, and that no other. Chlorophacinone is a diarylmethane and a betatriketone. Suspected of causing cancer very toxic to aquatic life precautionary statements. To go further in meeting our customers needs, certificates of analysis coa, material safety data sheets msds, and technical specifications are available for all our products online or upon request. Extinguishing media protective equipment and wear selfcontained breathing apparatus and protective clothing to prevent contact with skin and eyes. Material safety data sheet section 1 hydroquinone 1 chemical product and company identification msds name. Pure culture oxidation of hydroquinone produced 1,4benzoquinone, 2hydroxy1,4benzoquinone and betaketoadipic acid5. Material safety data sheet west liberty university.
Identification of the substancemixture and of the companyundertaking 1. A schimadzu lc9 was used with uv detector set at 295 nm having ods column 25 cm. The international agency for research on cancer iarc has classified hydroquinone in group 3, i. Despite the controversy, its abundantly clear is that hydroquinone is a wellresearched ingredient, incredibly effective for its intended purpose, and that no other skin lightening ingredient compares to its effectiveness. Melasma is blotchy brown discoloration of the face caused by pregnancy, birth control, normal female hormones and is exacerbated by the sun. Safety data sheet according to federal register vol.
Rats and mice were given hydroquinone by stomach tube or at high concentrations in the diet. The mobile phase was a mixture of water and ethanol 45. You also can through below form to request documents for moa,ros,1hnmr. Hydroquinone for cosmetic use is chemically synthesized. Headaches, dizziness, nausea, and cyanosis may result from overexposure to. Material safety data sheet eastman chemical company.
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